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Long-term outcomes of laparoscopic adrenalectomy for Cushing disease.
[cushing syndrome]
In
the
surgical
management
of
the
patients
with
Cushing
syndrome
(
CS
)
,
minimal
invasive
adrenalectomy
(
MA
)
has
become
the
procedure
of
choice
to
treat
adrenal
tumors
with
a
benign
appearance
≤
6
cm
in
diameter
.
Authors
evaluated
medium-
and
long
-term
outcomes
of
laparoscopic
adrenalectomy
(
LA
)
for
CS
or
subclinical
CS
(
sCS
)
,
performed
for
ten
years
in
an
endocrine
surgery
unit
.
We
retrospectively
reviewed
21
consecutive
patients
undergone
LA
for
CS
or
sCS
from
2003
to
2013
.
Postoperative
clinical
and
cardiovascular
status
modifications
and
surgical
medium
and
long
-term
outcomes
were
analyzed
.
In
each
patient
surgery
determined
a
normalization
of
the
hormonal
profile
.
There
was
no
mortality
neither
major
post-operative
complications
.
Mean
operative
time
was
higher
during
the
learning
curve
,
there
was
no
conversion
,
and
morbidity
rate
was
6
.
3
%
.
Regression
of
the
main
clinical
symptoms
occurred
slowly
in
twelve
months
.
LA
is
a
safe
,
effective
and
well-tolerated
procedure
for
the
treatment
of
CS
and
sCS
reducing
arterial
blood
pressure
,
body
weight
and
fasting
glucose
levels
.
Following
the
learning
curve
a
morbidity
rate
similar
to
that
reported
in
the
MA
series
for
other
adrenal
diseases
is
observed
.
Diseases
Validation
Diseases presenting
"long-term outcomes"
symptom
acute rheumatic fever
alpha-thalassemia
aromatase deficiency
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cushing syndrome
dystrophic epidermolysis bullosa
esophageal squamous cell carcinoma
hirschsprung disease
homocystinuria without methylmalonic aciduria
kabuki syndrome
lamellar ichthyosis
omenn syndrome
phenylketonuria
proteus syndrome
trochlear dysplasia
von hippel-lindau disease
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