Multiple endocrine neoplasia type IIa associated with Cushing's syndrome.

[cushing syndrome]

Multiple Endocrine Neoplasia type IIa (MEN IIa ) is an autosomal dominant syndrome characterized by pheochromocytoma , medullary thyroid carcinoma and hyperparathyroidism . Pheochromocytoma occurs in approximately 50 % of patients with MEN IIa . This tumor has the capacity to produce ACTH ectopically and manifests as the Cushing syndrome , although it is very rare . We report a 26 -year -old woman patient with severe muscle weakness , skin lesions in extremities , hypertension , and new onset diabetes whose laboratory findings included hypokalemia , metabolic alkalosis , high serum level of cortisol , metanephrine , normetanephrine , calcitonin and bilateral adrenal mass in computed tomography as the first clinical manifestations of an ACTH-secreting pheochromocytoma . In the patients with hypertension , new onset diabetes and hypokalemia , the Cushing syndrome and pheochromocytoma should always be ruled out .

Diseases
Validation

Diseases presenting "pheochromocytoma" symptom

adrenal incidentaloma

cowden syndrome

cushing syndrome

familial hypocalciuric hypercalcemia

holt-oram syndrome

proteus syndrome

von hippel-lindau disease

This symptom has already been validated