Small cerebellar cortex volume in patients with active Cushing's syndrome.

[cushing syndrome]

Cushing 's syndrome (CS ) is associated with neuropsychological deficits . As the cerebellum plays a key role in neuropsychological functions it may be affected in CS . The aim of this study was to investigate whether patients with CS have a smaller cerebellar volume than healthy controls , and to analyse whether cerebellar volume is associated with neuropsychological performance and clinical parameters .A cross-sectional study was performed .Thirty -six CS patients (15 with active CS and 21 with CS in remission ) and 36 controls matched for age , sex , and education underwent neuropsychological testing , quality of life assessment , clinical evaluation , and magnetic resonance imaging brain scan . Cerebellar volumes (white matter and cortex , bilateral ) were calculated using FreeSurfer Software .P atients with active CS showed smaller bilateral cerebellar cortex volumes than controls (left , P =0 .035 and right , P =0 .034 ), as well as a trend toward smaller right cerebellar cortex volumes than patients in remission CS (P =0 .051 ). No differences were observed in the volume of cerebellar white matter between the three groups . Both right and left cerebellar cortex volumes correlated negatively with triglyceride levels (right : r =-0 .358 , P =0 .002 and left : r =-0 .317 , P =0 .005 ) and age at diagnosis (right : r =-0 .433 , P =0 .008 and left : r =-0 .457 , P =0 .005 ). Left cerebellar cortex volume also correlated positively with visual memory performance (r =0 .245 , P =0 .038 ). Right cerebellar cortex volume positively correlated with quality-of-life scores (r =0 .468 , P =0 .004 ).The cerebellar cortex volume is smaller in active CS patients than in controls . This finding is associated with poor visual memory and quality of life and is mostly pronounced in patients with higher triglyceride levels and older age at diagnosis .

Diseases
Validation

Diseases presenting "poor visual memory" symptom

cushing syndrome

You can validate or delete this automatically detected symptom