Rare Diseases Symptoms Automatic Extraction
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Ectopic Cushing and other paraneoplastic syndromes in thoracic neuroendocrine tumors.
[cushing syndrome]
Overproduction
of
corticotropin
by
the
pituitary
gland
or
extrapituitary
tumors
leads
to
hypercortisolism
or
Cushing
syndrome
.
Diagnosis
of
suspected
Cushing
syndrome
involves
3
major
steps
:
confirmation
of
hypercortisolism
,
differentiation
between
corticotropin-independent
and
corticotropin-dependent
causes
of
Cushing
syndrome
,
and
distinction
between
pituitary
and
ectopic
corticotropin
production
.
A
definitive
diagnosis
of
ectopic
corticotropin
secretion
requires
stringent
criteria
,
including
reversal
of
the
clinical
picture
after
resection
of
the
tumor
and
/
or
demonstration
of
corticotropin
immunohistochemical
staining
within
the
tumor
tissue
.
