Persistent centripetal fat distribution and metabolic abnormalities in patients in long-term remission of Cushing's syndrome.

[cushing syndrome]

Centripetal obesity is associated with systemic low -grade inflammation and an increased cardiovascular risk . Patients in long -term remission of Cushing 's syndrome (CS ) report persisting abdominal fat accumulation . However , this has previously not been adequately objectified . Therefore we investigated the adipose tissue distribution and adipocytokine profiles of patients in long -term remission of CS .C ross sectional case-control study in a tertiary referral centre .Fifty -eight patients , in remission of CS for at least 5 years , were compared to 58 age-, gender- and BMI -matched healthy control subjects .measures of body composition (assessed with clinical evaluation and Dual Energy X-ray Absorptiometry (DEXA ) scanning ) and serum adipocytokine profiles .C ompared to the matched control subjects , patients in long -term remission of CS had a greater waist circumference (p <0 .01 ), a smaller thigh circumference (p <0 .01 ), a higher waist-to -hip ratio (p <0 .01 ) and a higher hip -to -thigh-ratio (p <0 .01 ). As measured with DEXA scanning , patients had a higher percentage of truncal fat mass (p =0 .01 ) and the truncal fat mass to leg fat mass ratio was greater (p <0 .01 ). Patients had lower adiponectin levels (p <0 .01 ), higher leptin levels (p <0 .01 ) and higher resistin levels (p =0 .04 ) than control subjects .Even after long -term remission , patients who suffered from CS in the past continue to have a centripetal adipose tissue distribution and an adverse adipokine profile . This is independent of etiology of the CS , treatment strategies , hormonal deficiencies and co -morbidity , and probably contributes to the persistent increased cardiovascular risk . This article is protected by copyright . All rights reserved .

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Diseases presenting "increased cardiovascular risk. patients in long-term remission" symptom

cushing syndrome

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