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A random Abstract
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Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes.
[cowden syndrome]
Characteristic
skin
neoplasms
are
associated
with
a
large
number
of
hereditary
tumor
syndromes
and
their
knowledge
and
early
detection
may
facilitate
the
diagnosis
of
the
underlying
malignancies
.
We
will
review
the
clinical
and
dermatopathological
aspects
of
cutaneous
and
visceral
lesions
and
the
recent
progresses
in
understanding
the
etiology
,
pathogenesis
and
therapies
of
selected
tumor
syndromes
.
The
skin
neoplasms
we
chose
to
consider
are
multiple
neurofibromas
in
neurofibromatosis
,
cylindromas
and
trichoepitheliomas
in
Broke-
Spiegler
syndrome
,
sebaceous
tumors
and
keratoacanthomas
in
Muir-
Torre
syndrome
,
Gardner
fibromas
in
Gardner
syndrome
,
multiple
basal
cell
carcinomas
in
nevoid
basal
cell
carcinoma
(
Gorlin
)
syndrome
,
multiple
tricholemmomas
in
Cowden
syndrome
,
multiple
fibrofolliculomas
in
Birt-
Hogg-
Dubé
syndrome
and
multiple
leiomyomas
in
hereditary
leiomyomatosis
and
renal
cell
cancer
.
Hereditary
cancers
have
distinct
biological
and
clinical
features
as
compared
to
their
sporadic
counterparts
;
for
this
reason
,
we
are
now
able
to
experiment
new
treatment
approaches
involving
not
only
tumor
detection
and
prevention
,
but
also
tailored
therapeutic
strategies
focusing
on
the
peculiar
druggable
molecular
targets
.
Diseases
Validation
Diseases presenting
"their knowledge and early detection may facilitate the diagnosis of the underlying malignancies"
symptom
cowden syndrome
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