Genetic testing by cancer site: uterus.

[cowden syndrome]

This review article discusses hereditary cancer predisposition syndromes with uterine manifestations . Lynch syndrome accounts for 2 % to 3 % of endometrial cancers . The identification of endometrial cancer patients at risk for Lynch syndrome is discussed , as are the characteristics of Lynch syndrome -associated endometrial cancer and the screening and prevention options for women at risk for Lynch syndrome -associated endometrial cancer . Endometrial cancer associated with PTEN hamartoma tumor syndrome (also known as Cowden syndrome ) is also discussed . HLRCC (hereditary leiomyomatosis and renal cell carcinoma ), which has an associated high risk of symptomatic uterine leiomyomas , is reviewed .