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A random Abstract
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Occult Breast Cancer due to Multiple Calcified Hamartomas in a Patient with Cowden Syndrome.
[cowden syndrome]
Cowden
syndrome
(
CS
)
is
an
autosomal
dominant
disorder
characterized
by
presence
of
multiple
hamartomas
,
and
other
benign
and
malignant
abnormalities
of
the
breasts
,
skin
,
thyroid
,
endometrium
,
gastrointestinal
tract
,
and
central
nervous
system
.
Hamartomas
are
benign
,
developmentally
disorganized
tumors
that
can
develop
in
any
of
the
above
mentioned
organs
.
The
presence
of
massive
calcifications
in
the
breasts
in
very
young
women
is
an
indication
to
perform
a
breast
MRI
to
exclude
a
neoplasm
since
,
like
in
the
current
case
report
,
presence
of
breast
calcifications
may
obscure
a
neoplasm
.
Although
fibrocystic
disease
and
cooccurrence
of
fibrocystic
disease
and
breast
cancer
are
much
more
common
than
CS
,
the
presence
of
massive
calcifications
in
the
breasts
of
very
young
women
should
elicit
the
possibility
of
an
underlying
genetic
disease
.
Furthermore
,
breast
cancer
and
macrocephaly
are
considered
major
criteria
for
the
diagnosis
of
CS
and
the
combination
of
both
is
enough
to
establish
the
clinical
diagnosis
of
this
entity
.
Fibrocystic
disease
of
the
breasts
and
multinodular
goiter
are
minor
criteria
.
Family
history
is
also
important
for
the
diagnosis
of
(
any
)
hereditary
disease
.
Diseases
Validation
Diseases presenting
"and central nervous system"
symptom
cowden syndrome
malignant atrophic papulosis
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