Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report.

[cowden syndrome]

The appearance of endometrial cancer in adolescence is uncommon and warrants investigation for an hereditary cancer syndrome . Cowden syndrome is an autosomal dominant cancer syndrome associated with a germline PTEN mutation and increased risk of breast , thyroid , endometrial and colon cancer . In this report we present a case of a 14 -year -old nulligravid female diagnosed with grade 1 endometrial adenocarcinoma . She subsequently developed fibrocystic breast disease and colon polyps and was diagnosed with Cowden syndrome at age 20 . We therefore recommend formal evaluation for Cowden syndrome to be considered when endometrial cancer is diagnosed in adolescence .