Rare Diseases Symptoms Automatic Extraction

Failure of secondary prophylaxis with erythromycin in rheumatic heart disease.

[acute rheumatic fever]

Erythromycin is recommended for secondary prophylaxis in children with rheumatic heart disease, who are allergic to penicillin.A 9-year-old girl, with rheumatic heart disease, on secondary prophylaxis with erythromycin 250 mg BD, presented with acute rheumatic fever.Responded to steroids and started on a higher dose (250 mg TDS) of erythromycin for secondary prophylaxis.There is need to document the resistance of group A streptococci to erythromycin.