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Corneal confocal microscopy anomalies associated with cowden syndrome: a case report.
[cowden syndrome]
To
describe
bilateral
corneal
alterations
through
confocal
microscopy
in
a
patient
affected
by
Cowden
syndrome
(
CS
)
.
Evaluation
of
Schirmer
's
,
fluorescein
,
and
lissamine
green
dye
tests
.
Confocal
microscopy
was
performed
in
both
eyes
to
investigate
corneal
abnormalities
.
Slit
lamp
observation
showed
the
focal
involvement
of
anterior
stromal
and
epithelial
layers
.
Schirmer
's
,
fluorescein
,
and
lissamine
green
dye
test
results
were
regular
,
while
corneal
confocal
examination
confirmed
the
disorganization
of
anterior
stromal
and
epithelial
layers
in
both
eyes
.
CS
is
a
rare
autosomal-dominant
systemic
disorder
.
In
our
case
,
confocal
analysis
revealed
predominance
of
alterations
in
the
anterior
stromal
corneal
layer
,
showing
an
increase
of
reflectivity
,
and
a
totally
unstructured
architecture
in
the
epithelium
layer
.
Even
though
the
main
purpose
remains
the
prevention
and
the
early
diagnosis
of
different
systemic
tumors
that
could
occur
in
affected
patients
,
corneal
confocal
evaluation
could
play
an
important
role
in
the
early
diagnosis
of
this
rare
disease
.
Diseases
Validation
Diseases presenting
"early diagnosis of this rare disease"
symptom
cowden syndrome
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