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Cowden Syndrome: report of a case and brief review of literature.
[cowden syndrome]
We
present
the
case
of
a
female
patient
with
facial
cutaneous
lesions
,
a
cobblestone-like
pattern
of
the
oral
mucosa
,
and
verruciform
lesions
on
the
hand
since
her
youth
.
She
reported
a
history
of
breast
cancer
,
endometrial
cancer
,
melanoma
and
multiple
benign
tumors
and
cysts
.
PTEN
gene
analysis
was
performed
and
confirmed
Cowden
Syndrome
,
a
rare
genodermatosis
with
an
autosomal
dominant
pattern
of
inheritance
,
characterized
by
multiple
hamartomas
.
The
phosphatase
and
tensin
homolog
(
PTEN
)
gene
negatively
regulates
cell
proliferation
and
cell
cycle
progression
.
Loss
of
PTEN
function
contributes
to
an
increased
risk
of
cancer
.
We
emphasize
the
importance
of
early
detection
and
accurate
management
of
Cowden
Syndrome
.