Rare Diseases Symptoms Automatic Extraction
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Chorea.
[acute rheumatic fever]
Chorea
is
an
involuntary
movement
disorder
characterised
by
flowing
and
rhythmic
in
nature
.
Hyperkinetic
movement
disorders
such
as
myoclonus
may
be
mistaken
for
chorea
.
Pathogenes
of
chorea
is
complex
and
results
from
dysfunction
of
network
between
motor
nucleus
of
thalamus
and
subcortical
nuclei
including
globus
pallidus
interna
.
There
are
genetic
and
non
genetic
causes
of
chorea
.
Huntington
's
disease
is
most
common
genetic
cause
of
chorea
.
Clinical
manifestations
of
Huntington
's
disease
are
mainly
neurological
and
psychiatric
.
Recently
non
neurological
clinical
manifestations
of
this
disease
have
been
described
.
Genetic
test
for
Huntington
's
disease
is
available
which
may
be
done
for
diagnosis
and
detection
of
family
members
at
risk
of
developing
disease
.
Other
genetic
causes
of
chorea
are
neuroacanthocytosis
and
Wilson
's
disease
.
Treatment
of
genetic
causes
of
chore
is
usually
symptomatic
with
exception
of
Wilson
's
disease
.
Sydenham
's
chorea
is
a
neurological
manifestation
of
acute
rheumatic
fever
and
most
important
cause
of
chorea
seen
in
paediatric
population
.
Treatment
includes
penicillin
prophylaxis
and
drugs
such
as
sodium
valproate
and
carbamazepine
.
Diagnosis
of
chorea
is
mainly
clinical
.
Family
history
is
very
important
in
diagnosis
of
genetic
causes
of
chorea
.
In
other
patients
a
detailed
work
up
is
required
before
a
final
diagnosis
is
made
.
Hematological
and
blood
chemistry
investigations
are
helpful
in
diagnosis
of
some
of
the
patients
.
Neuro
imaging
may
also
be
useful
mainly
in
Huntington
's
disease
patients
.
Metabolic
disorders
and
drugs
are
very
important
causes
of
non
genetic
chorea
.
Early
diagnosis
is
important
because
majority
of
the
patients
respond
to
the
treatment
.
