Persistent staining of lattice lines after intraoperative trypan blue use in patients with lattice corneal dystrophy.

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The aim of this study was to report the persistent staining of corneal lattice lines resulting from the intraoperative use of trypan blue .This is a case series .Four patients with lattice corneal dystrophy (LCD ) who underwent either deep anterior lamellar keratoplasty or cataract extraction with intraoperative trypan blue use demonstrated persistent , postoperative trypan staining of lattice lines on slit-lamp examination out to final follow-up (range , 176 to 541 days postoperatively ).This case series demonstrates the previously unreported finding that intraoperative trypan blue stains corneal lattice lines in LCD . Trypan blue staining , localized in previous laboratory studies to amyloid deposits , seems to persist for months or longer and may be permanent in human tissue . Although the staining was not visually significant , animal models suggest a stimulatory effect on progression of amyloidosis . Clinicians should be aware of the potential for permanent corneal staining and possible disease progression with the use of intraoperative trypan blue in patients with LCD .