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[Toxoplasmosis mother-to-child screening: study of cases followed in the Pasteur Institute of Tunis (2007-2010)].
[congenital toxoplasmosis]
Toxoplasmosis
when
occurring
during
pregnancy
can
be
transmitted
to
the
fetus
and
lead
to
congenital
toxoplasmosis
(
CT
)
.
Therefore
,
pregnant
women
are
a
risk
group
,
for
which
it
is
necessary
to
determine
the
serologic
profile
.
The
objective
of
this
study
is
to
determine
the
serologic
profile
of
toxoplasmosis
in
pregnant
women
followed
at
the
Parasitology
Laboratory
of
the
Pasteur
Institute
in
Tunis
,
to
establish
the
prevalence
of
toxoplasmic
infections
during
pregnancy
and
the
incidence
of
the
CT
,
noting
the
difficulties
faced
in
the
interpretation
of
serological
results
.
This
is
a
retrospective
study
concerning
2833
toxoplasmic
serologies
practiced
on
2070
pregnant
women
,
followed
at
the
Parasitology-
Mycology
Laboratory
of
the
Pasteur
Institute
of
Tunis
,
between
2007
and
2010
.
Serological
diagnosis
of
toxoplasmosis
was
done
by
ELISA
(
Enzyme
Linked
Immunosorbent
Assay
)
for
the
detection
of
Immunoglobulin
(
Ig
)
G
and
M
and
the
study
of
toxoplasmosis
IgG
avidity
.
Prenatal
diagnosis
was
performed
for
58
women
by
amniotic
fluid
sampling
.
Toxoplasma
gondii
was
detected
by
Polymerase
Chain
Reaction
(
PCR
)
.
At
birth
,
the
diagnosis
of
congenital
toxoplasmosis
was
established
based
on
serology
.
The
toxoplasmic
serologies
carried
out
have
shown
that
45
.
6
%
of
the
pregnant
women
were
formerly
immunized
while
49
.
6
%
had
a
negative
serology
.
A
toxoplasmosis
primary
infection
acquired
during
pregnancy
was
detected
in
79
cases
(
3
.
8
%
)
.
Among
them
,
33
%
had
a
true
seroconversion
while
67
%
had
a
recent
toxoplasmosis
infection
in
view
of
the
positivity
of
IgG
and
IgM
on
the
first
sample
with
a
low
index
of
avidity
(
IA
)
.
For
21
parturients
whose
serology
showed
the
presence
of
IgG
,
IgM
and
an
intermediate
or
high
IA
.
Among
the
58
parturients
in
whom
prenatal
diagnosis
was
performed
,
PCR
was
positive
in
four
cases
.
After
birth
,
six
cases
of
congenital
toxoplasmosis
were
detected
by
serology
.
Diseases
Validation
Diseases presenting
"prenatal diagnosis"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenomyeloneuropathy
alexander disease
alpha-thalassemia
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
classical phenylketonuria
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cystinuria
dentinogenesis imperfecta
epidermolysis bullosa simplex
harlequin ichthyosis
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kindler syndrome
krabbe disease
lamellar ichthyosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neonatal adrenoleukodystrophy
oculocutaneous albinism
omenn syndrome
phenylketonuria
primary hyperoxaluria type 1
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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