Rare Diseases Symptoms Automatic Extraction
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Acute rheumatic fever and streptococci: the quintessential pathogenic trigger of autoimmunity.
[acute rheumatic fever]
Acute
rheumatic
fever
(
ARF
)
is
a
non-suppurative
complication
of
pharyngeal
infection
with
group
A
streptococcus
.
Signs
and
symptoms
of
ARF
develop
2
to
3
Â
weeks
following
pharyngitis
and
include
arthritis
,
carditis
,
chorea
,
subcutaneous
nodules
,
and
erythema
marginatum
.
In
developing
areas
of
the
world
,
ARF
and
rheumatic
heart
disease
are
estimated
to
affect
nearly
20
million
people
and
remain
leading
causes
of
cardiovascular
death
during
the
first
five
decades
of
life
.
ARF
still
represents
one
of
the
quintessential
examples
of
a
pathogenic
trigger
culminating
in
autoimmune
manifestations
.
In
this
review
,
we
will
focus
on
the
pathogenesis
and
etiology
of
ARF
and
its
complications
,
along
with
diagnostic
and
treatment
approaches
to
both
ameliorate
and
prevent
long
-term
sequelae
of
this
potentially
debilitating
disease
.
Diseases
Validation
Diseases presenting
"erythema"
symptom
acute rheumatic fever
cowden syndrome
cutaneous mastocytosis
epidermolysis bullosa simplex
erythropoietic protoporphyria
familial mediterranean fever
harlequin ichthyosis
inclusion body myositis
kindler syndrome
lamellar ichthyosis
legionellosis
liposarcoma
malignant atrophic papulosis
neuralgic amyotrophy
omenn syndrome
pyomyositis
thoracic outlet syndrome
This symptom has already been validated
