Rare Diseases Symptoms Automatic Extraction
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Acute rheumatic fever and streptococci: the quintessential pathogenic trigger of autoimmunity.
[acute rheumatic fever]
Acute
rheumatic
fever
(
ARF
)
is
a
non-suppurative
complication
of
pharyngeal
infection
with
group
A
streptococcus
.
Signs
and
symptoms
of
ARF
develop
2
to
3
Â
weeks
following
pharyngitis
and
include
arthritis
,
carditis
,
chorea
,
subcutaneous
nodules
,
and
erythema
marginatum
.
In
developing
areas
of
the
world
,
ARF
and
rheumatic
heart
disease
are
estimated
to
affect
nearly
20
million
people
and
remain
leading
causes
of
cardiovascular
death
during
the
first
five
decades
of
life
.
ARF
still
represents
one
of
the
quintessential
examples
of
a
pathogenic
trigger
culminating
in
autoimmune
manifestations
.
In
this
review
,
we
will
focus
on
the
pathogenesis
and
etiology
of
ARF
and
its
complications
,
along
with
diagnostic
and
treatment
approaches
to
both
ameliorate
and
prevent
long
-term
sequelae
of
this
potentially
debilitating
disease
.
