Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Toxoplasma seroconversion with negative or transient immunoglobulin M in pregnant women: myth or reality? A French multicenter retrospective study.
[congenital toxoplasmosis]
Classically
,
Toxoplasma
infection
is
associated
with
high
levels
of
specific
IgM
antibody
and
a
rise
in
specific
IgG
levels
1
to
3
weeks
later
.
Atypical
IgG
seroconversion
,
without
IgM
detection
or
with
transient
IgM
levels
,
has
been
described
during
serologic
follow-up
of
seronegative
pregnant
women
and
raises
difficulties
in
interpreting
the
results
.
To
evaluate
the
frequency
and
the
characteristics
of
these
atypical
cases
of
seroconversion
,
an
investigation
was
conducted
within
the
French
National
Reference
Center
for
Toxoplasmosis
,
from
which
26
cases
collected
from
12
laboratories
belonging
to
the
network
were
identified
.
The
aim
of
this
work
was
to
retrospectively
analyze
the
results
of
serologic
testing
,
the
treatments
administered
,
and
the
results
of
prenatal
and
postnatal
follow-up
for
these
women
.
In
each
case
,
IgG
antibodies
were
detected
using
both
screening
and
confirmatory
tests
.
IgM
antibodies
were
not
detected
in
15
cases
,
and
the
levels
were
equivocal
or
low
-
positive
in
11
cases
.
The
IgG
avidity
results
were
low
in
16
cases
and
high
in
one
case
.
Most
of
the
pregnant
women
(
22
/
26
)
were
treated
with
spiramycin
from
the
time
that
IgG
antibodies
appeared
until
delivery
.
Amniotic
fluid
was
analyzed
for
Toxoplasma
gondii
DNA
by
PCR
in
11
/
26
cases
,
and
the
results
were
negative
in
all
cases
.
Congenital
toxoplasmosis
was
ruled
out
in
12
/
26
newborns
.
There
was
no
abnormality
observed
at
birth
for
10
newborns
and
no
information
available
for
4
newborns
.
In
conclusion
,
when
the
interpretation
of
serological
results
is
so
difficult
,
it
seems
cautious
to
initiate
treatment
by
spiramycin
and
to
follow
the
pregnant
women
and
their
newborns
.
Diseases
Validation
Diseases presenting
"raises difficulties in interpreting the results"
symptom
congenital toxoplasmosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom