Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Fibronectin degradation by MMP-2/MMP-9 in the serum of pregnant women and umbilical cord with Toxoplasma gondii infection.
[congenital toxoplasmosis]
It
has
been
suggested
that
in
congenital
Toxoplasma
gondii
infections
,
the
parasite
reaches
the
fetus
by
crossing
the
placental
barrier
.
The
purpose
of
this
study
was
to
determine
the
possible
relationships
between
matrix
metalloproteinases
(
MMPs
)
and
dysfunction
of
the
placental
barrier
in
gravidas
infected
with
T
.
gondii
.
We
studied
26
umbilical
cord
sera
;
20
and
6
were
derived
from
gravidas
seropositive
for
anti-
T
.
gondii
IgG
and
seropositive
for
anti-
T
.
gondii
IgM
(
low
IgG
avidity
)
,
respectively
.
Of
20
cord
blood
samples
,
18
were
seropositive
for
T
.
gondii
IgG
,
whereas
all
cord
blood
samples
were
seronegative
for
T
.
gondii
IgM
.
The
other
six
sera
were
seronegative
for
T
.
gondii
IgG
,
whereas
three
of
six
sera
were
seropositive
for
T
.
gondii
IgM
.
Furthermore
,
T
.
gondii
induced
an
increase
in
MMP-
2
and
-
9
secretion
in
the
sera
of
gravidas
and
umbilical
cords
.
Moreover
,
MMP-
2
and
-
9
were
interacted
with
fibronectin
.
We
propose
that
MMP-
2
and
-
9
may
be
involved
in
ECM
degradation
and
placental
barrier
dysfunction
,
which
facilitates
T
.
gondii
transmission
to
the
fetus
.
Future
investigations
of
the
effect
of
MMPs
on
migration
across
epithelial
and
endothelial
barriers
will
be
important
to
establish
the
mechanism
of
transit
.