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Age-associated prevalence of Toxoplasma gondii in 8281 pregnant women in Poland between 2004 and 2012.
[congenital toxoplasmosis]
This
study
aimed
to
describe
Toxoplasma
gondii
prevalence
in
Polish
pregnant
women
and
the
incidence
rates
of
congenital
infections
in
their
neonates
observed
between
2004
and
2012
.
Serological
tests
for
T
.
gondii-
specific
IgG
and
IgM
antibodies
were
performed
on
serum
samples
of
8281
pregnant
women
treated
at
the
Polish
Mother
's
Memorial
Hospital
Research
Institute
in
Lodz
.
The
yearly
seroconversion
rate
for
T
.
gondii
IgG
antibodies
was
estimated
using
a
mathematical
model
to
determine
the
dependency
between
age
and
prevalence
.
Mean
prevalence
of
IgG
antibodies
between
2004
and
2012
in
pregnant
women
was
40
·
6
%
[
95
%
confidence
interval
(
CI
)
39
·
6
-
41
·
7
]
and
increased
with
age
with
a
yearly
seroconversion
rate
of
0
·
8
%
(
95
%
CI
0
·
6
-
1
·
0
,
P
<
0
·
001
)
.
Assuming
a
T
.
gondii
materno-
fetal
transmission
rate
of
30
%
gave
an
estimate
of
1
·
80
/
1000
neonates
as
congenitally
infected
.
The
increased
mean
age
(
28
·
7
vs
26
·
7
years
,
P
<
0
·
001
)
of
pregnant
women
was
probably
the
most
important
factor
in
abolishing
the
effect
of
falling
prevalence
rates
.