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The global burden of congenital toxoplasmosis: a systematic review.
[congenital toxoplasmosis]
To
estimate
the
global
burden
of
congenital
toxoplasmosis
(
CT
)
,
which
results
from
infection
of
pregnant
women
with
Toxoplasma
gondii
.
The
authors
systematically
searched
9
major
databases
for
published
and
unpublished
sources
and
established
direct
contact
with
the
authors
of
source
materials
.
Searches
were
country-
specific
.
To
be
included
,
studies
had
to
report
on
the
incidence
of
CT
,
on
positivity
to
Toxoplasma-
specific
IgM
in
infants
and
pregnant
women
(
including
seroconversion
results
)
or
on
positivity
to
Toxoplasma-
specific
IgG
in
the
general
population
.
Various
modelling
techniques
were
used
,
depending
on
the
country-
specific
data
available
,
to
estimate
the
CT
incidence
and
burden
in
each
country
.
These
data
were
then
synthesized
into
an
estimate
of
the
global
incidence
of
CT
and
of
the
global
burden
of
CT
in
disability-adjusted
life
years
(
DALYs
)
.
The
global
annual
incidence
of
congenital
toxoplasmosis
was
estimated
to
be
190
,
100
cases
(
95
%
credible
interval
,
CI
:
179
,
300
-
206
,
300
)
.
This
was
equivalent
to
a
burden
of
1
.
20
million
DALYs
(
95
%
CI
:
0
.
76
-
1
.
90
)
.
High
burdens
were
seen
in
South
America
and
in
some
Middle
Eastern
and
low
-income
countries
.
Congenital
toxoplasmosis
poses
a
substantial
burden
of
poor
health
globally
.
Toxoplasmosis
should
be
included
in
future
updates
of
the
global
burden
of
disease
and
the
corresponding
data
should
be
used
to
support
public
health
interventions
to
reduce
disease
burden
.
Diseases
Validation
Diseases presenting
"poor health"
symptom
congenital toxoplasmosis
inclusion body myositis
legionellosis
severe combined immunodeficiency
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