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Molecular Genotyping of Toxoplasma gondii in Human Spontaneous Aborted Fetuses in Shiraz, Southern Iran.
[congenital toxoplasmosis]
Congenital
toxoplasmosis
is
associated
with
variable
complications
including
encephalitis
,
microcephaly
,
hydrocephaly
,
hepatitis
,
lymphadenopathy
and
even
intrauterine
death
.
Presence
of
Toxoplasma
gondii
in
human
placenta
may
induce
congenital
infection
.
The
aim
of
this
study
was
to
determine
the
genotypes
of
Toxoplasma
gondii
infection
in
human
spontaneous
aborted
fetuses
in
Shiraz
,
south
of
Iran
.
F
ive
hundred
and
forty
two
paraffin-embedded
blocks
of
aborted
placenta
were
collected
,
from
two
university-affiliated
hospitals
in
Shiraz
.
Occurrence
of
spontaneous
abortion
was
confirmed
by
examine
of
the
slides
.
After
re
-cutting
of
the
blocks
and
dewaxing
,
semi-nested
PCR
assay
was
used
to
detect
the
fragments
of
T
.
gondii
B
1
gene
in
the
samples
.
Also
direct
molecular
genotyping
was
performed
on
positive
samples
with
Restriction
Fragment
Length
Polymorphism-
PCR
analysis
on
the
SAG
2
gene
.
Among
the
542
tissue
samples
,
the
B
1
gene
was
amplified
from
78
(
14
.
4
%
)
of
cases
with
the
semi
nested
PCR
and
typed
by
RFLP
.
The
genotype
of
Toxoplasma
strains
of
65
(
out
of
78
)
PCR-
positive
samples
were
evaluated
and
54
out
of
65
(
83
.
1
%
)
were
found
to
be
type
II
and
11
out
of
65
(
16
.
9
%
)
were
type
I
.
Considering
the
high
level
of
Toxoplasma
infection
in
aborted
fetuses
in
this
study
,
Toxoplasma
might
largely
contribute
to
spontaneous
abortion
in
this
area
of
Iran
.
Diseases
Validation
Diseases presenting
"high level"
symptom
22q11.2 deletion syndrome
aniridia
cadasil
carcinoma of the gallbladder
cohen syndrome
congenital toxoplasmosis
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentinogenesis imperfecta
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
hodgkin lymphoma, classical
inclusion body myositis
liposarcoma
lymphangioleiomyomatosis
omenn syndrome
oral submucous fibrosis
pyomyositis
scrub typhus
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
x-linked adrenoleukodystrophy
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