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A random Abstract
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Our Team
Congenital toxoplasmosis.
[congenital toxoplasmosis]
Infection
with
Toxoplasma
gondii
is
asymptomatic
or
mild
in
immunocompetent
people
and
leads
to
lifelong
immunity
,
but
it
can
have
serious
consequences
in
pregnancy
.
About
five
per
1000
non-immune
pregnant
women
may
acquire
toxoplasma
infection
,
with
a
10
%
to
100
%
risk
of
transmission
to
the
baby
.
Risks
of
transmission
to
the
baby
are
higher
later
in
pregnancy
,
but
risks
of
infection
causing
harm
to
the
baby
are
greater
earlier
in
pregnancy
.
We
conducted
a
systematic
review
and
aimed
to
answer
the
following
clinical
questions
:
What
are
the
effects
on
mother
and
baby
of
treating
toxoplasmosis
during
pregnancy
to
reduce
risk
of
vertical
transmission
and
treat
fetal
infection
?
What
are
the
effects
of
treating
toxoplasmosis
in
neonates
infected
with
toxoplasmosis
prenatally
?
We
searched
:
Medline
,
Embase
,
The
Cochrane
Library
,
and
other
important
databases
up
to
June
2013
(
Clinical
Evidence
reviews
are
updated
periodically
;
please
check
our
website
for
the
most
up-
to
-date
version
of
this
review
)
.
We
included
harms
alerts
from
relevant
organisations
such
as
the
US
Food
and
Drug
Administration
(
FDA
)
and
the
UK
Medicines
and
Healthcare
products
Regulatory
Agency
(
MHRA
)
.
We
found
six
systematic
reviews
,
RCTs
,
or
observational
studies
that
met
our
inclusion
criteria
.
We
performed
a
GRADE
evaluation
of
the
quality
of
evidence
for
interventions
.
In
this
systematic
review
we
present
information
relating
to
the
effectiveness
and
safety
of
the
following
interventions
:
antiparasitic
drugs
in
pregnancy
,
and
antiparasitic
drugs
in
neonates
.