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Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis.
[congenital toxoplasmosis]
to
investigate
the
rate
of
positivity
for
immunoglobulin
M
anti-
Toxoplasma
gondii
(
Toxo-
IgM
)
in
newborns
with
congenital
toxoplasmosis
,
and
the
age
when
these
antibodies
become
negative
.
patients
with
congenital
toxoplasmosis
who
started
monitoring
in
a
congenital
infection
clinic
between
1998
and
2009
were
included
.
Inclusion
criteria
were
routine
maternal
or
neonatal
serological
screening
;
diagnostic
confirmation
by
persistence
of
immunoglobulin
G
anti-
Toxoplasma
gondii
at
age
≥
12
months
,
and
Toxo-
IgM
screening
in
the
neonatal
period
.
To
calculate
the
frequency
of
positive
Toxo-
IgM
,
cases
detected
by
neonatal
screening
were
excluded
.
For
the
study
of
the
age
when
Toxo-
IgM
results
became
negative
,
patients
with
negative
Toxo-
IgM
since
birth
and
those
in
whom
it
was
not
possible
to
identify
the
month
when
the
negative
result
was
achieved
were
excluded
.
among
the
28
patients
identified
through
maternal
screening
,
23
newborns
had
positive
Toxo-
IgM
(
82
.
1
%
,
95
%
CI
:
64
.
7
-
93
.
1
%
)
.
When
adding
the
37
patients
identified
by
neonatal
screening
,
Toxo-
IgM
was
positive
in
the
first
month
of
life
in
60
patients
,
and
it
was
possible
to
identify
when
the
result
became
negative
in
51
of
them
.
In
19
.
6
%
of
patients
,
these
antibodies
were
already
negative
at
30
days
of
life
;
and
in
54
.
9
%
,
at
90
days
.
Among
the
65
patients
included
in
the
study
,
40
(
61
.
5
%
)
had
some
clinical
alteration
.
even
with
high
sensitivity
methods
,
newborns
with
congenital
toxoplasmosis
can
have
negative
Toxo-
IgM
at
birth
.
In
those
who
have
these
antibodies
,
the
positive
period
may
be
quite
short
.
It
is
important
not
to
interrupt
the
monitoring
of
infants
with
suspected
congenital
toxoplasmosis
simply
because
they
present
a
negative
Toxo-
IgM
result
.
Diseases
Validation
Diseases presenting
"suspected congenital toxoplasmosis"
symptom
congenital toxoplasmosis
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