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Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis.
[congenital toxoplasmosis]
to
investigate
the
rate
of
positivity
for
immunoglobulin
M
anti-
Toxoplasma
gondii
(
Toxo-
IgM
)
in
newborns
with
congenital
toxoplasmosis
,
and
the
age
when
these
antibodies
become
negative
.
patients
with
congenital
toxoplasmosis
who
started
monitoring
in
a
congenital
infection
clinic
between
1998
and
2009
were
included
.
Inclusion
criteria
were
routine
maternal
or
neonatal
serological
screening
;
diagnostic
confirmation
by
persistence
of
immunoglobulin
G
anti-
Toxoplasma
gondii
at
age
≥
12
months
,
and
Toxo-
IgM
screening
in
the
neonatal
period
.
To
calculate
the
frequency
of
positive
Toxo-
IgM
,
cases
detected
by
neonatal
screening
were
excluded
.
For
the
study
of
the
age
when
Toxo-
IgM
results
became
negative
,
patients
with
negative
Toxo-
IgM
since
birth
and
those
in
whom
it
was
not
possible
to
identify
the
month
when
the
negative
result
was
achieved
were
excluded
.
among
the
28
patients
identified
through
maternal
screening
,
23
newborns
had
positive
Toxo-
IgM
(
82
.
1
%
,
95
%
CI
:
64
.
7
-
93
.
1
%
)
.
When
adding
the
37
patients
identified
by
neonatal
screening
,
Toxo-
IgM
was
positive
in
the
first
month
of
life
in
60
patients
,
and
it
was
possible
to
identify
when
the
result
became
negative
in
51
of
them
.
In
19
.
6
%
of
patients
,
these
antibodies
were
already
negative
at
30
days
of
life
;
and
in
54
.
9
%
,
at
90
days
.
Among
the
65
patients
included
in
the
study
,
40
(
61
.
5
%
)
had
some
clinical
alteration
.
even
with
high
sensitivity
methods
,
newborns
with
congenital
toxoplasmosis
can
have
negative
Toxo-
IgM
at
birth
.
In
those
who
have
these
antibodies
,
the
positive
period
may
be
quite
short
.
It
is
important
not
to
interrupt
the
monitoring
of
infants
with
suspected
congenital
toxoplasmosis
simply
because
they
present
a
negative
Toxo-
IgM
result
.
Diseases
Validation
Diseases presenting
"neonatal period"
symptom
alexander disease
alpha-thalassemia
benign recurrent intrahepatic cholestasis
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cutaneous mastocytosis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
harlequin ichthyosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
pyruvate dehydrogenase deficiency
zellweger syndrome
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