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A random Abstract
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Overlapping Toxoplasma gondii genotypes circulating in domestic animals and humans in Southeastern Brazil.
[congenital toxoplasmosis]
Although
several
Toxoplasma
gondii
genotyping
studies
have
been
performed
in
Brazil
,
studies
of
isolates
from
animals
in
the
state
of
Minas
Gerais
are
rare
.
The
objective
of
this
study
was
to
conduct
a
genotypic
characterization
of
T
.
gondii
isolates
obtained
from
dogs
,
free-range
chickens
,
and
humans
in
Minas
Gerais
and
to
verify
whether
the
T
.
gondii
genotypes
circulating
in
domestic
animals
correspond
to
the
genotypes
detected
in
humans
.
Genetic
variability
was
assessed
by
restricted
fragment
length
polymorphism
at
11
loci
(
SAG
1
,
5
'
+
3
'
SAG
2
,
SAG
2
alt
,
SAG
3
,
BTUB
,
GRA
6
,
c
22
-
8
,
c
29
-
2
,
L
358
,
PK
1
,
and
Apico
)
.
Twelve
different
genotypes
were
identified
among
the
24
isolates
studied
,
including
8
previously
identified
genotypes
and
4
new
genotypes
.
The
genetic
relationship
of
the
24
T
.
gondii
isolates
,
together
with
the
genotypes
previously
described
from
24
human
newborns
with
congenital
toxoplasmosis
,
revealed
a
high
degree
of
similarity
among
the
genotypes
circulating
in
humans
and
animals
in
Minas
Gerais
.
The
most
common
genotypes
among
these
species
were
BrII
,
BrIII
,
ToxoDB
#
108
,
and
ToxoDB
#
206
.
Restricted
fragment
length
polymorphism
at
the
CS
3
locus
of
these
48
isolates
showed
that
the
majority
of
isolates
presented
alleles
I
(
50
%
)
or
II
(
27
%
)
.
Isolates
harboring
allele
III
at
the
CS
3
locus
presented
low
virulence
for
mice
,
whereas
those
harboring
alleles
I
or
II
presented
higher
virulence
.
These
results
confirm
the
utility
of
marker
CS
3
for
predicting
the
virulence
of
Brazilian
isolates
of
T
.
gondii
in
mice
.
No
association
was
found
between
the
allele
type
and
clinical
manifestations
of
human
congenital
toxoplasmosis
.
This
is
the
first
report
of
T
.
gondii
genotyping
that
verifies
the
overlapping
genotypes
of
T
.
gondii
from
humans
and
animals
in
the
same
geographic
region
of
Brazil
.
Our
results
suggest
that
there
is
a
common
source
of
infection
to
the
species
studied
,
most
likely
oocysts
contaminating
the
environment
.
Diseases
Validation
Diseases presenting
"common source"
symptom
congenital toxoplasmosis
werner syndrome
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