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A random Abstract
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Overlapping Toxoplasma gondii genotypes circulating in domestic animals and humans in Southeastern Brazil.
[congenital toxoplasmosis]
Although
several
Toxoplasma
gondii
genotyping
studies
have
been
performed
in
Brazil
,
studies
of
isolates
from
animals
in
the
state
of
Minas
Gerais
are
rare
.
The
objective
of
this
study
was
to
conduct
a
genotypic
characterization
of
T
.
gondii
isolates
obtained
from
dogs
,
free-range
chickens
,
and
humans
in
Minas
Gerais
and
to
verify
whether
the
T
.
gondii
genotypes
circulating
in
domestic
animals
correspond
to
the
genotypes
detected
in
humans
.
Genetic
variability
was
assessed
by
restricted
fragment
length
polymorphism
at
11
loci
(
SAG
1
,
5
'
+
3
'
SAG
2
,
SAG
2
alt
,
SAG
3
,
BTUB
,
GRA
6
,
c
22
-
8
,
c
29
-
2
,
L
358
,
PK
1
,
and
Apico
)
.
Twelve
different
genotypes
were
identified
among
the
24
isolates
studied
,
including
8
previously
identified
genotypes
and
4
new
genotypes
.
The
genetic
relationship
of
the
24
T
.
gondii
isolates
,
together
with
the
genotypes
previously
described
from
24
human
newborns
with
congenital
toxoplasmosis
,
revealed
a
high
degree
of
similarity
among
the
genotypes
circulating
in
humans
and
animals
in
Minas
Gerais
.
The
most
common
genotypes
among
these
species
were
BrII
,
BrIII
,
ToxoDB
#
108
,
and
ToxoDB
#
206
.
Restricted
fragment
length
polymorphism
at
the
CS
3
locus
of
these
48
isolates
showed
that
the
majority
of
isolates
presented
alleles
I
(
50
%
)
or
II
(
27
%
)
.
Isolates
harboring
allele
III
at
the
CS
3
locus
presented
low
virulence
for
mice
,
whereas
those
harboring
alleles
I
or
II
presented
higher
virulence
.
These
results
confirm
the
utility
of
marker
CS
3
for
predicting
the
virulence
of
Brazilian
isolates
of
T
.
gondii
in
mice
.
No
association
was
found
between
the
allele
type
and
clinical
manifestations
of
human
congenital
toxoplasmosis
.
This
is
the
first
report
of
T
.
gondii
genotyping
that
verifies
the
overlapping
genotypes
of
T
.
gondii
from
humans
and
animals
in
the
same
geographic
region
of
Brazil
.
Our
results
suggest
that
there
is
a
common
source
of
infection
to
the
species
studied
,
most
likely
oocysts
contaminating
the
environment
.
Diseases
Validation
Diseases presenting
"first report"
symptom
achondroplasia
alexander disease
aniridia
cadasil
canavan disease
child syndrome
cohen syndrome
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
harlequin ichthyosis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
homocystinuria without methylmalonic aciduria
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
pendred syndrome
pleomorphic liposarcoma
primary hyperoxaluria type 1
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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