Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil.
[congenital toxoplasmosis]
This
study
describes
the
characteristics
of
31
children
with
congenital
toxoplasmosis
children
admitted
to
the
University
Hospital
of
Londrina
,
Southern
Brazil
,
from
2000
to
2010
.
In
total
,
23
(
85
.
2
%
)
of
the
mothers
received
prenatal
care
but
only
four
(
13
.
0
%
)
were
treated
for
toxoplasmosis
.
Birth
weight
was
<
2500
g
in
37
.
9
%
of
the
infants
.
During
the
first
month
of
life
,
physical
examination
was
normal
in
34
.
5
%
,
and
for
those
with
clinical
signs
and
symptoms
,
the
main
manifestations
were
hepatomegaly
and
/
or
splenomegaly
(
62
.
1
%
)
,
jaundice
(
13
.
8
%
)
,
and
microcephaly
(
6
.
9
%
)
.
During
ophthalmic
examination
,
74
.
2
%
of
the
children
exhibited
injuries
,
58
.
1
%
chorioretinitis
,
32
.
3
%
strabismus
,
19
.
4
%
microphthalmia
,
and
16
.
2
%
vitreitis
.
Anti-
Toxoplasma
gondii
IgM
antibodies
were
detected
in
48
.
3
%
of
the
children
.
Imaging
brain
evaluation
was
normal
in
44
.
8
%
;
brain
calcifications
,
hydrocephaly
,
or
both
conditions
were
observed
in
27
.
6
%
,
10
.
3
%
,
and
17
.
2
%
,
respectively
,
of
the
patients
.
Patients
with
cerebrospinal
fluid
protein
≥
200
mg
/
dL
presented
more
brain
calcifications
(
p
=
0
.
0325
)
.
Other
sequelae
were
visual
impairment
(
55
.
2
%
of
the
cases
)
,
developmental
delay
(
31
.
0
%
)
,
motor
deficit
(
13
.
8
%
)
,
convulsion
(
27
.
5
%
)
,
and
attention
deficit
(
10
.
3
%
)
.
All
patients
were
treated
with
sulfadiazine
,
pyrimethamine
,
and
folinic
acid
,
and
55
.
2
%
of
them
exhibited
adverse
effects
.
The
results
demonstrate
the
significance
of
the
early
diagnosis
and
treatment
of
toxoplasmosis
during
pregnancy
to
reduce
congenital
toxoplasmosis
and
its
consequences
.
Diseases
Validation
Diseases presenting
"jaundice"
symptom
alpha-thalassemia
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
cholangiocarcinoma
congenital toxoplasmosis
erythropoietic protoporphyria
esophageal carcinoma
homocystinuria without methylmalonic aciduria
megacystis-microcolon-intestinal hypoperistalsis syndrome
neonatal adrenoleukodystrophy
oculocutaneous albinism
phenylketonuria
scrub typhus
typhoid
von hippel-lindau disease
This symptom has already been validated
