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Congenital toxoplasmosis presenting as central diabetes insipidus in an infant: a case report.
[congenital toxoplasmosis]
Congenital
toxoplasmosis
has
a
wide
range
of
presentation
at
birth
varying
from
severe
neurological
features
such
as
hydrocephalus
and
chorioretinitis
to
a
well
appearing
baby
,
who
may
develop
complications
late
in
infancy
.
While
neuroendocrine
abnormalities
associated
with
congenital
toxoplasmosis
are
uncommon
,
isolated
central
diabetes
insipidus
is
extremely
rare
.
Here
,
we
report
on
a
female
infant
who
presented
with
fever
,
convulsions
,
and
polyuria
.
Examination
revealed
weight
and
length
below
the
3rd
centile
along
with
signs
of
severe
dehydration
.
Fundal
examination
showed
bilateral
chorioretinitis
.
This
infant
developed
hypernatremia
together
with
increased
serum
osmolality
and
decreased
both
urine
osmolality
and
specific
gravity
consistent
with
central
diabetes
insipidus
.
Serology
for
toxoplasma
specific
immunoglobulin
M
was
high
for
both
the
mother
and
the
baby
and
polymerase
chain
reaction
for
toxoplasma
deoxyribonucleic
acid
was
positive
in
the
infant
confirming
congenital
toxoplasmosis
.
Brain
computerized
tomography
scans
demonstrated
ventriculomegaly
associated
with
cerebral
and
cortical
calcifications
.
Fluid
and
electrolyte
abnormalities
responded
to
nasal
vasopressin
therapy
.
This
report
highlights
central
diabetes
inspidus
as
a
rare
presentation
of
congenital
toxoplasmosis
.
Diseases
Validation
Diseases presenting
"ventriculomegaly"
symptom
achondroplasia
alexander disease
congenital toxoplasmosis
hydrocephalus with stenosis of the aqueduct of sylvius
monosomy 21
pyruvate dehydrogenase deficiency
This symptom has already been validated