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[Toxoplasmic infections in pregnancy: about 94 cases diagnosed at the Pasteur Institute of Tunis].
[congenital toxoplasmosis]
The
objectives
of
this
study
were
to
estimate
the
risk
of
maternal
-
fetal
transmission
of
toxoplasmosis
and
its
consequences
on
the
fetus
and
to
emphasize
the
importance
of
follow-up
of
newborns
in
Tunisia
.
It
was
a
retrospective
study
of
94
cases
of
pergravidic
toxoplasmic
seroconversion
who
were
diagnosed
and
followed
in
the
Laboratory
of
Parasitology
of
Pasteur
Institute
of
Tunis
between
2005
and
2010
.
In
our
series
,
amniocentesis
was
performed
for
60
parturients
.
Among
the
amniotic
fluid
tested
,
research
of
toxoplasmosis
DNA
by
PCR
was
positive
in
12
cases
(
12
/
60
,
20
%
)
.
Twenty
-
six
cases
of
congenital
toxoplasmosis
were
diagnosed
with
14
postnatal
cases
.
The
rate
of
maternal
-
fetal
transmission
of
Toxoplasma
gondii
was
27
.
6
%
(
26
/
94
)
.
This
risk
increases
with
gestational
age
,
from
19
%
at
seroconversion
of
the
1
st
quarter
to
29
.
4
%
in
the
2nd
quarter
and
44
.
4
%
in
the
3rd
trimester
.
Monitoring
of
newborns
with
congenital
toxoplasmosis
showed
that
only
3
children
were
symptomatic
.
There
were
2
cases
of
toxoplasmic
chorioretinitis
and
a
case
of
brain
damage
.
Under
serological
monitoring
of
newborns
,
21
cases
were
lost
to
follow-up
and
monitoring
was
stopped
for
29
after
decrease
of
anti-toxoplasmic
IgG
.
T
he
prenatal
diagnosis
allowed
to
decrease
the
severe
forms
of
congenital
toxoplasmosis
in
Tunisia
.
Nevertheless
,
it
is
always
necessary
to
raise
the
problem
of
the
significant
number
of
newborn
children
whose
follow-up
is
incomplete
.
