Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Effect of pyrimethamine treatment on male rat testicular cell population development.
[congenital toxoplasmosis]
Pyrimethamine
(
PYR
)
is
a
drug
used
in
the
treatment
of
newborn
with
congenital
Toxoplasmosis
.
Even
when
PYR
is
highly
specific
against
parasites
,
it
may
provoke
neutropenia
in
the
patients
apart
from
other
affectations
,
conditions
that
usually
justify
its
suspension
.
Moreover
,
medication
against
congenital
toxoplasmosis
coincides
with
the
proliferation
stage
of
Sertoli
and
germ
cells
.
Although
,
there
are
several
reports
on
the
effect
of
this
drug
on
mature
testes
,
records
of
its
effects
on
the
testes
of
young
individuals
yet
in
the
process
of
growth
are
still
lacking
.
This
work
was
aimed
to
study
the
effects
of
in
vivo
administration
of
PYR
in
the
first
21
days
of
life
of
male
rat
pups
by
evaluating
their
testicular
alterations
and
its
long
-term
sequels
on
fertility
.
Through
the
determination
of
the
levels
of
seminiferous
epithelium
maturity
,
apoptotic
index
and
cell
proliferation
index
at
7
,
14
,
35
and
90
days
post-
natal
using
immunocytochemical
studies
.
The
fertility
of
the
treated
rats
was
evaluated
at
90
days
.
PYR-treated
animals
were
found
to
undergo
some
kind
of
delays
in
seminiferous
epithelium
maturity
,
decreased
cell
proliferation
index
and
an
increase
in
apoptosis
when
compared
with
the
control
(
p
<
0
.
05
)
.
Epididymal
sperm
counts
were
also
affected
(
p
<
0
.
05
)
.
The
application
of
folic
acid
(
FA
)
in
newborns
treated
with
PYR
decreased
the
severity
of
the
problem
(
p
<
0
.
05
)
.
This
study
provides
strong
evidence
that
the
effect
of
PYR
on
testicular
development
is
specific
.
It
reinforces
the
importance
of
FA
application
in
neonates
treated
with
PYR
to
prevent
the
effect
of
the
later
on
spermatogenesis
.
