Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Assessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy.
[congenital toxoplasmosis]
The
different
laboratory
methods
used
in
the
diagnosis
of
congenital
toxoplasmosis
have
variable
sensitivity
and
specificity
.
There
is
no
evidence
to
prove
that
maternal
treatment
reduces
the
risk
of
fetal
infection
.
The
purpose
of
this
study
was
to
assess
methods
for
the
confirmation
of
congenital
toxoplasmosis
after
maternal
treatment
with
spiramycin
during
pregnancy
,
and
to
evaluate
the
effect
of
this
treatment
on
clinical
manifestations
of
the
disease
in
newborns
(
NB
)
.
This
was
a
community-based
,
cross-sectional
study
of
acute
toxoplasmosis
in
newborns
at
risk
of
acquiring
congenital
infection
.
Participating
newborns
were
born
in
the
Clinical
Hospital
Maternity
Ward
of
the
Federal
University
of
Goiás
.
Eligible
participants
were
divided
into
2
groups
:
group
1
consisted
of
44
newborns
born
to
mothers
treated
with
spiramycin
during
pregnancy
and
group
2
consisted
of
24
newborns
born
to
mothers
not
treated
with
spiramycin
during
pregnancy
because
the
diagnosis
of
toxoplasmosis
was
not
performed
.
The
sensitivity
and
specifity
of
PCR
for
T
.
gondii
DNA
in
peripheral
blood
and
serological
testing
for
specific
anti-
T
.
gondii
IgM
and
IgA
,
and
the
effects
of
maternal
spiramycin
treatment
on
these
parameters
,
were
determined
by
associating
test
results
with
clinical
manifestations
of
disease
.
The
sensitivity
of
the
markers
(
T
.
gondii
DNA
detected
by
PCR
,
and
the
presence
of
specific
anti-
T
.
gondii
IgM
and
IgA
)
for
congenital
toxoplasmosis
was
higher
in
group
2
than
in
group
1
(
31
.
6
,
68
.
4
,
36
.
8
%
and
3
.
7
,
25
.
9
,
11
.
1
%
respectively
)
.
Even
with
a
low
PCR
sensitivity
,
the
group
2
results
indicate
the
importance
of
developing
new
techniques
for
the
diagnosis
of
congenital
toxoplasmosis
in
newborns
.
Within
group
1
,
70
.
4
%
of
the
infected
newborns
were
asymptomatic
and
,
in
group
2
,
68
.
4
%
showed
clinical
manifestations
of
congenital
toxoplasmosis
.
The
higher
proportion
of
infants
without
clinical
symptoms
in
group
1
(
70
.
4
%
)
suggests
the
maternal
treatment
with
spiramycin
delays
fetal
infection
,
reducing
the
clinical
sequelae
of
the
disease
in
newborns
.
Given
the
low
sensitivity
of
the
tests
used
,
when
there
is
suspicion
of
congenital
transmission
several
serological
and
parasitological
tests
are
required
in
order
to
confirm
or
exclude
congenital
toxoplasmosis
in
newborns
.
Diseases
Validation
Diseases presenting
"peripheral blood"
symptom
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
aniridia
cohen syndrome
congenital toxoplasmosis
cutaneous mastocytosis
erdheim-chester disease
esophageal adenocarcinoma
esophageal squamous cell carcinoma
familial mediterranean fever
gm1 gangliosidosis
junctional epidermolysis bullosa
lamellar ichthyosis
monosomy 21
oligodontia
omenn syndrome
scrub typhus
severe combined immunodeficiency
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom