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Intervention Strategies to Reduce Human Toxoplasma gondii Disease Burden.
[congenital toxoplasmosis]
Infection
with
Toxoplasma
gondii
is
acquired
through
consumption
of
undercooked
infected
meat
,
or
by
uptake
of
cat-shed
oocysts
.
Although
congenital
toxoplasmosis
is
generally
considered
to
contribute
most
to
the
disease
burden
of
T
.
gondii
,
ocular
disease
from
acquired
infection
was
recently
shown
to
add
substantially
to
the
burden
.
In
addition
,
toxoplasmosis
in
immune-compromised
individuals
usually
results
from
reactivation
of
an
infection
acquired
earlier
in
life
.
Nevertheless
,
prevention
of
toxoplasmosis
commonly
targets
mainly
pregnant
women
.
We
summarize
current
prevention
strategies
of
congenital
toxoplasmosis
and
evaluate
options
to
improve
protection
of
the
general
population
(
including
pregnant
women
)
.
To
protect
the
general
population
,
freezing
of
meat
destined
for
raw
or
undercooked
consumption
is
the
most
readily
applicable
option
,
especially
when
limited
to
meat
from
animals
originating
from
nonbiosecure
husbandry
systems
.
In
the
long
term
,
more
health
benefits
are
expected
from
cat
vaccination
;
therefore
,
development
of
a
cat
vaccine
and
evaluation
of
its
implementation
is
a
research
priority
.
Diseases
Validation
Diseases presenting
"especially when limited to meat from animals originating from nonbiosecure husbandry systems"
symptom
congenital toxoplasmosis
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