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Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic hernia.
[congenital diaphragmatic hernia]
The
reported
incidence
of
sensorineural
hearing
loss
(
SNHL
)
in
long
-term
survivors
of
congenital
diaphragmatic
hernia
varies
widely
in
the
literature
.
Conductive
hearing
loss
(
CHL
)
is
also
known
to
occur
in
CDH
patients
,
but
has
been
less
widely
studied
.
We
sought
to
characterize
the
incidence
and
risk
factors
associated
with
SNHL
and
CHL
in
a
large
cohort
of
CDH
patients
who
underwent
standardized
treatment
and
follow-up
at
a
single
institution
.
We
retrospectively
reviewed
charts
of
all
CDH
patients
in
our
pulmonary
hypoplasia
program
from
January
2004
through
December
2012
.
Categorical
variables
were
analyzed
by
Fisher
's
exact
test
and
continuous
variables
by
Mann-
Whitney
t-test
(
p
≤
0
.
05
)
.
A
total
of
112
patients
met
study
inclusion
criteria
,
with
3
(
2
.
7
%
)
patients
diagnosed
with
SNHL
and
38
(
34
.
0
%
)
diagnosed
with
CHL
.
SNHL
was
significantly
associated
with
requirement
for
ECMO
(
p
=
0
.
0130
)
,
prolonged
course
of
hospitalization
(
p
=
0
.
0011
)
,
duration
of
mechanical
ventilation
(
p
=
0
.
0046
)
,
requirement
for
tracheostomy
(
p
=
0
.
0013
)
,
and
duration
of
loop
diuretic
(
p
=
0
.
0005
)
and
aminoglycoside
therapy
(
p
=
0
.
0003
)
.
We
have
identified
hearing
anomalies
in
over
30
%
of
long
-term
CDH
survivors
.
These
findings
illustrate
the
need
for
routine
serial
audiologic
evaluations
throughout
childhood
for
all
survivors
of
CDH
and
stress
the
importance
of
targeted
interventions
to
optimize
long
-term
developmental
outcomes
pertaining
to
speech
and
language
.
Diseases
Validation
Diseases presenting
"sensorineural hearing loss"
symptom
canavan disease
congenital diaphragmatic hernia
dentin dysplasia
dentinogenesis imperfecta
hirschsprung disease
holt-oram syndrome
monosomy 21
pendred syndrome
triple a syndrome
This symptom has already been validated