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Sensorineural hearing loss in congenital diaphragmatic hernia survivors is associated with postnatal management and not defect size.
[congenital diaphragmatic hernia]
We
determined
the
incidence
of
sensorineural
hearing
loss
(
SNHL
;
>
20
dB
at
any
frequency
)
in
a
contemporary
cohort
of
congenital
diaphragmatic
hernia
(
CDH
)
survivors
at
a
single
tertiary
care
center
and
identified
potential
risk
factors
for
SNHL
.
From
2000
through
2011
,
clinical
and
audiologic
data
were
collected
on
122
surgically-repaired
Bochdalek
CDH
patients
.
CDH
defect
size
,
duration
of
ventilation
,
and
cumulative
aminoglycoside
treatment
were
used
for
multivariate
logistic
regression
.
Incidence
of
SNHL
was
7
.
4
%
(
9
/
122
)
.
We
identified
one
significant
independent
predictor
of
SNHL
:
cumulative
length
of
aminoglycoside
treatment
(
P
<
.
001
;
OR
1
.
44
,
95
%
CI
:
1
.
13
-
1
.
83
)
.
Over
the
last
decade
,
the
incidence
of
SNHL
in
our
CDH
patients
is
low
compared
to
previous
reports
in
the
literature
(
7
.
4
%
)
and
is
not
associated
with
CDH
defect
size
or
the
need
for
extracorporeal
membrane
oxygenation
.
Prolonged
duration
of
aminoglycoside
treatment
increases
the
risk
of
SNHL
independent
of
defect
size
and
duration
of
ventilation
.
