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Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia.
[congenital diaphragmatic hernia]
It
has
been
shown
that
pulmonary
retinol
level
is
decreased
during
lung
morphogenesis
in
the
nitrofen-induced
PH
in
congenital
diaphragmatic
hernia
(
CDH
)
.
Placenta
has
a
major
role
in
the
retinol
homeostasis
in
fetal
life
.
Since
there
is
no
fetal
retinol
synthesis
,
maternal
retinol
has
to
cross
the
placenta
.
Placenta
is
the
main
fetal
retinol
store
where
retinol
is
stored
in
retinyl-
ester
formation
.
Trophoblasts
have
to
produce
its
own
retinol-binding
protein
(
RBP
)
for
retinol
transport
from
placenta
to
fetus
.
Recently
,
we
demonstrated
that
trophoblastic
RBP
expression
is
decreased
in
the
nitrofen
model
of
CDH
.
The
aim
of
this
study
was
to
investigate
the
retinol
transfer
from
mother
to
the
placenta
in
nitrofen
model
of
CDH
.
Pregnant
rats
were
exposed
to
either
olive
oil
or
nitrofen
on
day
9
of
gestation
(
D
9
)
.
Fetal
placenta
harvested
on
D
21
and
divided
into
two
groups
:
control
(
n
=
11
)
and
nitrofen
with
CDH
(
n
=
11
)
.
Retinoid
levels
in
placenta
were
measured
using
HPLC
.
Immunohistochemistry
was
performed
to
evaluate
trophoblastic
expression
of
main
RSP
genes
.
Total
retinol
levels
in
the
placenta
were
significantly
increased
in
CDH
placenta
compared
to
control
placenta
.
The
retinyl-
ester
levels
were
significantly
increased
in
CDH
placenta
compared
to
control
placenta
.
Markedly
,
decreased
immunoreactivity
of
retinoid
signaling
pathway
was
observed
in
trophoblast
cells
in
CDH
compared
to
control
placenta
.
Increased
placental
retinol
levels
show
that
retinol
is
transferred
from
mother
to
placenta
and
stored
in
the
placenta
in
nitrofen
model
of
CDH
during
lung
morphogenesis
.
Nitrofen
may
disturb
the
mobilization
of
retinol
from
placenta
to
fetal
circulation
causing
PH
in
CDH
.
