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Foetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia--a systemic review and meta-analysis of randomized controlled trials.
[congenital diaphragmatic hernia]
To
evaluate
and
analyze
the
effect
of
foetal
endocsopic
tracheal
occlusion
(
FETO
)
therapy
on
survival
rates
of
neonatal
with
congenital
diaphragmatic
hernia
and
maternal
complications
.
We
performed
a
systemic
review
and
meta
-analysis
of
three
randomized
controlled
trials
(
RCTs
)
.
The
combined
data
on
neonatal
survival
rates
,
length
of
gestational
age
and
rates
of
premature
rupture
of
membrane
from
these
studies
were
retrieved
and
analysed
.
Pooled
data
of
these
three
RCTs
revealed
that
FETO
provided
neonates
with
severe
congenital
diaphragmatic
hernia
a
significantly
higher
survival
rate
:
27
/
48
VS
12
/
52
.
The
odds
ratio
was
5
.
95
(
95
%
CI
:
2
.
11
-
16
.
79
,
p
<
0
.
0008
)
.
The
gestational
age
(
week
)
of
FETO
group
was
shorter
than
postnatal
standard
therapy
group
.
The
mean
difference
was
-
3
.
43
(
95
%
CI
:
-
6
.
82
-
-
0
.
04
,
p
<
0
.
05
)
.
FETO
group
also
had
a
significantly
greater
rate
of
premature
rupture
of
membranes
than
control
group
with
the
odds
ratio
of
3
.
35
(
95
%
CI
:
2
.
11
-
16
.
79
,
p
<
0
.
0008
)
.
Foetal
endoscopic
tracheal
occlusion
improved
neonatal
survival
rate
but
also
increased
major
maternal
complications
including
preterm
delivery
and
premature
rupture
of
membranes
.
