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Fetal lung growth represented by longitudinal changes in MRI-derived fetal lung volume parameters predicts survival in isolated left-sided congenital diaphragmatic hernia.
[congenital diaphragmatic hernia]
To
evaluate
fetal
lung
growth
rate
for
isolated
left-sided
CDH
using
serial
MRI-based
volumetric
measures
.
Early
and
late
gestational
(
22
-
30
and
>
30
weeks
'
gestation
)
lung
volumetry
was
obtained
by
fetal
MRI
in
47
cases
of
isolated
left-sided
CDH
.
At
both
of
these
time
points
,
lung
volume
indices
,
including
total
lung
volume
(
TLV
)
,
observed
to
expected
TLV
(
o
/
e
TLV
)
,
and
percentage
of
predicted
lung
volume
(
PPLV
)
as
well
as
their
change
rates
(
∆
)
and
relative
∆
during
gestation
were
calculated
and
analyzed
in
regard
to
their
capacity
to
predict
neonatal
survival
.
TLV
,
o
/
e
TLV
,
and
PPLV
had
various
changes
during
gestation
.
Late
TLV
,
early
and
late
o
/
e
TLV
,
and
late
PPLV
were
predictive
of
neonatal
survival
.
Non-survivors
had
lower
∆
TLV
and
more
negative
relative
∆
PPLV
than
survivors
(
1
.
18
mL
/
wk
vs
1
.
85
mL
/
wk
,
P
=
0
.
004
and
-
4
.
15
%
/
wk
vs
-
1
.
95
%
/
wk
,
P
=
0
.
002
,
respectively
)
.
The
severity
of
pulmonary
hypoplasia
is
dynamic
and
can
worsen
in
the
third
trimester
.
MRI
lung
volumetry
repeated
in
late
gestation
can
provide
additional
information
on
individual
lung
growth
that
may
facilitate
prenatal
counseling
and
focus
perinatal
management
.
This
article
is
protected
by
copyright
.
All
rights
reserved
.
Diseases
Validation
Diseases presenting
"late gestation"
symptom
alpha-thalassemia
congenital diaphragmatic hernia
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