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Effect of corticosteroids and lung ventilation in the VEGF and NO pathways in congenital diaphragmatic hernia in rats.
[congenital diaphragmatic hernia]
The
use
of
dexamethasone
(
Dx
)
stimulates
growth
,
fetal
lung
maturation
and
can
improve
pulmonary
hypertension
in
congenital
diaphragmatic
hernia
(
CDH
)
.
Our
aim
was
to
evaluate
the
effect
of
Dx
on
the
lung
after
fetal
pulmonary
ventilation
in
the
CDH
rat
model
.
Some
groups
underwent
prenatal
treatment
with
dexamethasone
(
0
.
4
mg
/
kg
)
that
was
given
at
18
.
5
gestational
day
(
GD
)
.
Sprague-
Dawley
rat
fetuses
were
divided
into
groups
:
control
(
C
)
;
ventilated
control
(
CV
)
;
control
exposed
to
dexamethasone
(
CDx
)
;
ventilated
control
exposed
to
dexamethasone
(
CVDx
)
;
congenital
diaphragmatic
hernia
(
CDH
)
,
ventilated
CDH
(
CDHV
)
,
CDH
exposed
to
dexamethasone
(
CDHDx
)
and
ventilated
CDH
exposed
to
dexamethasone
(
CDHVDx
)
.
At
21
.
5
GD
fetuses
were
delivered
by
C-
section
,
weighed
and
ventilated
for
30
min
.
We
analyzed
the
lung
morphometry
by
Masson
's
Trichrome
stain
,
and
VEGF
,
VEGFR
1
,
VEGFR
2
and
NOS
3
expression
by
immunohistochemistry
.
All
fetuses
with
CDH
,
with
or
without
prenatal
dexamethasone
showed
lung
and
body
weight
lower
than
control
fetuses
(
p
<
0
.
05
)
.
All
groups
that
received
dexamethasone
showed
a
decrease
in
the
medial
muscular
layer
of
arterioles
,
the
internal
diameter
of
the
air
spaces
(
Lma
)
and
length
of
parenchymal
transection
/
airspace
ratio
(
p
<
0
.
05
)
.
In
the
immunohistochemistry
,
VEGF
decreased
more
in
CDHDV
group
(
p
<
0
.
05
)
.
VEGFR
1
showed
no
difference
,
whereas
VEGFR
2
decreased
significantly
in
the
CDHDV
group
(
p
<
0
.
05
)
.
NOS
3
increased
in
the
group
CDHDV
(
p
<
0
.
05
)
.
The
use
of
prenatal
dexamethasone
added
to
ventilation
alters
the
VEGF
and
NO
pathways
.
Diseases
Validation
Diseases presenting
"lung maturation"
symptom
congenital diaphragmatic hernia
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