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Plasma gelsolin as a biomarker of acute rheumatic carditis.
[acute rheumatic fever]
Acute
rheumatic
fever
is
an
autoimmune
,
inflammatory
,
and
multi-systemic
disease
secondary
to
pharyngitis
and
is
caused
by
group
A
streptococcus
.
In
developing
countries
,
acute
rheumatic
fever
is
the
most
common
cause
of
acquired
heart
disease
.
Gelsolin
is
a
calcium
-dependent
,
multi-
functional
actin-regulatory
protein
circulating
in
the
plasma
of
healthy
human
beings
.
The
correlation
between
blood
gelsolin
levels
and
inflammatory
conditions
suggests
the
potential
benefit
of
gelsolin
as
a
prognostic
marker
.
The
aim
of
the
present
study
was
to
appraise
the
association
of
gelsolin
and
acute
rheumatic
carditis
in
childhood
.
Materials
and
Methods
Plasma
gelsolin
levels
were
measured
and
echocardiographic
examinations
were
performed
in
patients
(
n
=
37
)
with
acute
rheumatic
carditis
and
compared
with
those
of
age-
and
gender-matched
healthy
controls
(
n
=
24
)
.
The
plasma
gelsolin
levels
in
children
with
acute
rheumatic
carditis
were
significantly
lower
compared
with
controls
(
197
±
218
versus
322
±
255
mg
/
L
,
p
=
0
.
039
)
.
There
was
a
significant
correlation
among
gelsolin
levels
and
the
grade
of
mitral
regurgitation
(
p
=
0
.
030
)
,
left
ventricular
end-diastolic
diameter
(
p
=
0
.
017
)
,
and
left
ventricular
end-systolic
diameter
(
p
=
0
.
028
)
at
diagnosis
.
Levels
of
the
gelsolin
plasma
isoform
were
decreased
in
patients
with
acute
rheumatic
carditis
compared
with
healthy
controls
.
Gelsolin
may
be
used
as
a
biochemical
marker
for
acute
rheumatic
carditis
.
Diseases
Validation
Diseases presenting
"common cause"
symptom
achondroplasia
acute rheumatic fever
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
alpha-thalassemia
aniridia
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
child syndrome
coats disease
congenital adrenal hyperplasia
congenital toxoplasmosis
cushing syndrome
erdheim-chester disease
esophageal adenocarcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
lamellar ichthyosis
legionellosis
liposarcoma
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
pendred syndrome
primary hyperoxaluria type 1
pyruvate dehydrogenase deficiency
scrub typhus
systemic capillary leak syndrome
thoracic outlet syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
zellweger syndrome
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