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Plasma gelsolin as a biomarker of acute rheumatic carditis.
[acute rheumatic fever]
Acute
rheumatic
fever
is
an
autoimmune
,
inflammatory
,
and
multi-systemic
disease
secondary
to
pharyngitis
and
is
caused
by
group
A
streptococcus
.
In
developing
countries
,
acute
rheumatic
fever
is
the
most
common
cause
of
acquired
heart
disease
.
Gelsolin
is
a
calcium
-dependent
,
multi-
functional
actin-regulatory
protein
circulating
in
the
plasma
of
healthy
human
beings
.
The
correlation
between
blood
gelsolin
levels
and
inflammatory
conditions
suggests
the
potential
benefit
of
gelsolin
as
a
prognostic
marker
.
The
aim
of
the
present
study
was
to
appraise
the
association
of
gelsolin
and
acute
rheumatic
carditis
in
childhood
.
Materials
and
Methods
Plasma
gelsolin
levels
were
measured
and
echocardiographic
examinations
were
performed
in
patients
(
n
=
37
)
with
acute
rheumatic
carditis
and
compared
with
those
of
age-
and
gender-matched
healthy
controls
(
n
=
24
)
.
The
plasma
gelsolin
levels
in
children
with
acute
rheumatic
carditis
were
significantly
lower
compared
with
controls
(
197
±
218
versus
322
±
255
mg
/
L
,
p
=
0
.
039
)
.
There
was
a
significant
correlation
among
gelsolin
levels
and
the
grade
of
mitral
regurgitation
(
p
=
0
.
030
)
,
left
ventricular
end-diastolic
diameter
(
p
=
0
.
017
)
,
and
left
ventricular
end-systolic
diameter
(
p
=
0
.
028
)
at
diagnosis
.
Levels
of
the
gelsolin
plasma
isoform
were
decreased
in
patients
with
acute
rheumatic
carditis
compared
with
healthy
controls
.
Gelsolin
may
be
used
as
a
biochemical
marker
for
acute
rheumatic
carditis
.
Diseases
Validation
Diseases presenting
"heart disease"
symptom
22q11.2 deletion syndrome
achondroplasia
acute rheumatic fever
adrenal incidentaloma
child syndrome
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
dentinogenesis imperfecta
esophageal adenocarcinoma
fabry disease
familial mediterranean fever
heparin-induced thrombocytopenia
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kabuki syndrome
monosomy 21
omenn syndrome
phenylketonuria
sneddon syndrome
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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