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Subthreshold psychotic symptoms in 22q11.2 deletion syndrome.
[22q11.2 deletion syndrome]
Chromosome
22
q
11
.
2
deletion
syndrome
(
22
q
11
DS
)
confers
25
%
risk
for
psychosis
and
is
an
invaluable
window
for
understanding
the
neurobiological
substrate
of
psychosis
risk
.
The
Structured
Interview
for
Prodromal
Syndromes
(
SIPS
)
is
well
validated
in
nondeleted
populations
for
detecting
clinical
risk
but
has
only
recently
been
applied
to
22
q
11
DS
.
We
assessed
the
largest
22
q
11
DS
cohort
to
date
and
report
on
SIPS
implementation
and
symptoms
elicited
.
The
SIPS
,
including
its
19
subscales
,
was
administered
to
157
individuals
with
22
q
11
DS
aged
8
to
25
years
.
Youth
and
caregiver
interviews
were
conducted
and
rated
separately
,
then
compared
for
agreement
.
Implementation
of
the
SIPS
in
22
q
11
DS
was
challenging
because
of
the
prevalence
of
developmental
delay
and
comorbid
conditions
.
However
,
by
explaining
questions
and
eliciting
examples
,
we
were
able
to
help
youths
and
caregivers
understand
and
respond
appropriately
.
Consensus
ratings
were
formulated
and
analyzed
with
itemwise
and
factor
analysis
.
Subthreshold
symptoms
were
common
,
with
85
%
of
individuals
endorsing
1
or
more
.
The
most
commonly
rated
items
were
ideational
richness
(
47
%
)
and
trouble
with
focus
and
attention
(
44
%
)
.
Factor
analysis
revealed
a
3
-
factor
solution
with
positive
,
negative
,
and
disorganized
components
.
Youth-caregiver
comparisons
suggested
that
youths
report
greater
symptoms
of
perceptual
abnormalities
,
suspiciousness
,
trouble
with
emotional
expression
,
and
bizarre
thinking
.
Caregivers
reported
more
impaired
tolerance
to
normal
stress
,
poor
hygiene
,
and
inattention
.
The
SIPS
was
adapted
for
22
q
11
DS
through
comprehensive
and
semi-structured
administration
methods
,
yielding
a
high
prevalence
of
subthreshold
psychotic
symptoms
.
The
significance
and
predictive
validity
of
these
symptoms
require
future
longitudinal
analysis
.
Diseases
Validation
Diseases presenting
"psychosis"
symptom
22q11.2 deletion syndrome
child syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
sneddon syndrome
This symptom has already been validated
