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Acne as a chronic systemic disease.
[congenital adrenal hyperplasia]
Acne
is
the
most
common
skin
disorder
.
In
the
majority
of
cases
,
acne
is
a
disease
that
changes
its
skin
distribution
and
severity
over
time
;
moreover
,
it
can
be
a
physically
(
scar
development
)
and
psychologically
damaging
condition
that
lasts
for
years
.
According
to
its
clinical
characteristics
,
it
can
be
defined
as
a
chronic
disease
according
to
the
World
Health
Organization
criteria
.
Acne
is
also
a
cardinal
component
of
many
systemic
diseases
or
syndromes
,
such
as
congenital
adrenal
hyperplasia
,
seborrhea
-
acne
-
hirsutism
-androgenetic
alopecia
syndrome
,
polycystic
ovarian
syndrome
,
hyperandrogenism-
insulin
resistance
-
acanthosis
nigricans
syndrome
,
Apert
syndrome
,
synovitis-
acne
-pustulosis-
hyperostosis
-osteitis
syndrome
,
and
pyogenic
arthritis
-
pyoderma
gangrenosum
-
acne
syndrome
.
Recent
studies
on
the
Ache
hunter
gatherers
of
Paraguay
detected
the
lack
of
acne
in
association
with
markedly
lower
rates
of
obesity
,
diabetes
mellitus
,
hyperlipidemia
,
and
cardiovascular
diseases
,
a
finding
that
indicates
either
a
nutritional
or
a
genetic
background
of
this
impressive
concomitance
.
Diseases
Validation
Diseases presenting
"hyperostosis-osteitis syndrome"
symptom
congenital adrenal hyperplasia
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