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[Congenital adrenal hyperplasia in the adult women: management of old and new challenges].
[congenital adrenal hyperplasia]
Due
to
major
improvements
in
the
management
and
therapy
of
patients
with
congenital
adrenal
hyperplasia
owing
to
21
-
hydroxylase
deficiency
(
21
OHD
)
along
childhood
and
adolescence
,
affected
women
are
able
to
reach
adulthood
.
Therefore
,
management
throughout
adult
life
became
even
more
complex
,
leading
to
new
challenges
.
Both
the
protracted
use
of
corticosteroids
(
sometimes
in
supraphysiologic
doses
)
,
and
excess
androgen
(
due
to
irregular
treatment
and
/
or
inadequate
dosage
)
may
impair
the
quality
of
life
and
health
outcomes
in
affected
adult
women
,
causing
osteoporosis
,
metabolic
disturbances
with
high
cardiovascular
risk
,
cosmetic
damage
,
infertility
,
and
psychosocial
and
psychosexual
changes
.
However
,
long
-term
follow-up
studies
with
21
OHD
adult
women
are
still
required
.
In
this
review
,
we
discuss
some
important
and
controversial
aspects
of
the
follow-up
of
adult
women
with
21
OHD
,
and
recommend
the
use
of
a
customized
multi-disciplinary
therapeutic
approach
while
further
studies
with
these
patients
do
not
provide
distinct
understanding
and
well-defined
attitudes
towards
better
quality
of
life
.
Diseases
Validation
Diseases presenting
"osteoporosis"
symptom
achondroplasia
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
aromatase deficiency
congenital adrenal hyperplasia
cushing syndrome
cutaneous mastocytosis
dentinogenesis imperfecta
erythropoietic protoporphyria
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
inclusion body myositis
kallmann syndrome
oligodontia
pyomyositis
werner syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated