Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models.
[congenital adrenal hyperplasia]
Despite
increasing
acknowledgement
of
hormonal
contributions
to
mood
and
anxiety
disorders
,
the
underlying
mechanisms
by
which
gonadal
hormones
influence
psychopathology-related
behaviours
remain
unknown
.
This
review
focuses
on
recent
research
that
examines
the
influence
of
gonadal
steroid
hormones
,
including
androgens
,
oestrogens
,
and
progesterone
,
on
mood
and
anxiety
-related
behaviours
in
human
health
and
disease
.
To
this
aim
,
the
literature
was
surveyed
for
studies
that
assess
conditions
with
suspected
underlying
hormonal
imbalances
in
otherwise
healthy
participants
(
e
.
g
.
,
premenstrual
dysphoric
disorder
,
postmenopausal
depression
)
as
well
as
conditions
linked
to
congenital
endocrine
abnormalities
(
e
.
g
.
,
Turner
Syndrome
,
Klinefelter
Syndrome
,
polycystic
ovary
syndrome
,
congenital
adrenal
hyperplasia
,
familial
male
precocious
puberty
,
androgen
insensitivity
syndrome
)
.
Furthermore
,
to
better
inform
clinical
work
and
to
create
a
translational
bridge
,
a
second
goal
was
to
set
human
psychopathologies
and
animal
models
of
these
conditions
side-
by
-side
.
In
the
second
part
of
the
review
,
based
on
consistencies
revealed
in
the
existing
literature
across
conditions
,
a
new
model
for
the
impact
of
gonadal
hormones
on
anxious
and
depressed
behavioural
states
is
proposed
.
Finally
,
we
conclude
by
proposing
directions
for
future
research
,
including
the
development
of
specific
tasks
suitable
for
cross-species
comparisons
to
increase
our
knowledge
of
the
role
of
gonadal
hormones
in
mood
and
anxiety
.
Diseases
Validation
Diseases presenting
"based on consistencies revealed in the existing literature across conditions"
symptom
congenital adrenal hyperplasia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom