Periodontal findings in Cohen syndrome with chronic neutropenia.

[cohen syndrome]

Radiographic periodontal status and microbiological findings of periodontal pockets in subjects with Cohen syndrome are presented in this report . This hereditary disorder causes mental retardation , and neutropenia is one feature of the syndrome . Fifteen patients with Cohen syndrome and 15 controls matched for age and sex and , as far as possible , according to the degree of mental retardation were examined . Alveolar bone loss was evaluated from the panoramic radiographs . Two subgingival samples were obtained from the most affected anterior and posterior periodontal sites in each dentate subject and examined for the occurrence of Actinobacillus actinomycetemcomitans , Porphyromonas gingivalis , Prevotella intermedia /nigrescens , Peptostreptococcus micros , Bacteroides forsythus , and Campylobacter rectus . Subjects with Cohen syndrome had alveolar bone loss more frequently and the bone loss was more extensive (Mann-Whitney U-test : P < 0 .05 ) than in the controls . They also harbored one or several of the putative periodontal pathogens (Mann-Whitney U-test : P < 0 .001 ) more often than the controls . We conclude that subjects with Cohen syndrome have increased susceptibility to early periodontal breakdown which is likely to be associated with neutropenia .

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cohen syndrome

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