Metabolic syndrome manifestations in Cohen syndrome: description of two new patients.

[cohen syndrome]

We report on sporadic cases that have the proposed diagnostic criteria for Cohen syndrome associated with metabolic syndrome . The patients , aged 14 and 16 years , had truncal obesity , mild mental retardation , hypotonia , narrow hands and feet , a high-arched palate , prominent upper central incisors , a high nasal bridge , and ocular abnormalities . Both had impaired glucose tolerance , with marked hyperinsulinemia exhibited by an oral glucose tolerance test . Moreover , they had the other metabolic syndrome features of hyperlipidemia and hypertension . We suggest that it is necessary to consider the possibility of metabolic syndrome in a case of Cohen syndrome .

Diseases
Validation

Diseases presenting "hypertension" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

aniridia

aromatase deficiency

cadasil

child syndrome

cohen syndrome

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cushing syndrome

cystinuria

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

fabry disease

familial hypocalciuric hypercalcemia

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

holt-oram syndrome

homocystinuria without methylmalonic aciduria

hydrocephalus with stenosis of the aqueduct of sylvius

inclusion body myositis

kallmann syndrome

kindler syndrome

lamellar ichthyosis

lymphangioleiomyomatosis

pendred syndrome

primary effusion lymphoma

scrub typhus

severe combined immunodeficiency

sneddon syndrome

typhoid

von hippel-lindau disease

well-differentiated liposarcoma

werner syndrome

x-linked adrenoleukodystrophy

zellweger syndrome

This symptom has already been validated