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A random Abstract
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VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae.
[cohen syndrome]
The
hereditary
disorders
chorea
acanthocytosis
and
Cohen
syndrome
are
caused
by
mutations
in
different
members
of
a
family
of
genes
that
are
orthologs
of
yeast
VPS
13
.
In
vegetatively
growing
yeast
,
VPS
13
is
involved
in
the
delivery
of
proteins
to
the
vacuole
.
During
sporulation
,
VPS
13
is
important
for
formation
of
the
prospore
membrane
that
encapsulates
the
daughter
nuclei
to
give
rise
to
spores
.
We
report
that
VPS
13
is
required
for
multiple
aspects
of
prospore
membrane
morphogenesis
.
VPS
13
(
1
)
promotes
expansion
of
the
prospore
membrane
through
regulation
of
phosphatidylinositol
phosphates
,
which
in
turn
activate
the
phospholipase
D
,
Spo
14
;
(
2
)
is
required
for
a
late
step
in
cytokinesis
that
gives
rise
to
spores
;
and
(
3
)
regulates
a
membrane-bending
activity
that
generates
intralumenal
vesicles
.
These
results
demonstrate
that
Vps
13
plays
a
broader
role
in
membrane
biology
than
previously
known
,
which
could
have
important
implications
for
the
functions
of
VPS
13
orthologs
in
humans
.