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The effect of intravitreal bevacizumab in the treatment of Coats disease in children.
[coats disease]
The
purpose
of
this
study
was
to
determine
if
intravitreal
bevacizumab
can
reduce
subretinal
exudates
and
exudative
retinal
detachment
and
facilitate
the
treatment
of
Coats
disease
in
children
.
Prospective
,
interventional
,
and
noncomparative
case
series
of
three
eyes
in
three
children
with
Coats
disease
were
studied
.
All
eyes
received
only
intravitreal
bevacizumab
injection
as
the
primary
treatment
.
Ablative
procedures
,
including
cryotherapy
,
traditional
continuous
wave
laser
,
or
subthreshold
diode
micropulse
laser
,
for
diseased
vessels
were
performed
after
subretinal
fluid
totally
reabsorbed
.
One
supplementary
intravitreal
bevacizumab
injection
was
given
after
ablative
procedures
on
the
same
day
.
The
changes
in
pre-
and
postoperative
best-corrected
visual
acuity
were
recorded
.
Serial
color
fundus
photography
,
optical
coherence
tomography
,
and
B-
scan
sonography
were
performed
to
measure
treatment
efficacy
.
After
receiving
one
to
three
injections
,
all
three
patients
had
subretinal
fluid
completely
reabsorbed
.
All
patients
had
one
session
of
subsequent
ablative
procedures
for
diseased
vessels
and
supplementary
intravitreal
bevacizumab
injection
.
No
patients
had
recurrent
subretinal
fluid
.
Improved
visual
acuity
was
noted
in
two
cases
but
was
not
detectable
in
the
other
.
No
ocular
or
systemic
complications
related
to
bevacizumab
were
noted
during
the
entire
course
of
follow-up
.
Intravitreal
bevacizumab
appears
to
be
a
well-tolerated
treatment
for
children
with
Coats
disease
.
A
favorable
response
is
observed
when
compared
with
other
treatment
modalities
.
It
has
the
potential
as
an
adjuvant
therapy
of
vascular
ablative
procedures
to
improve
final
vision
and
facilitate
ongoing
treatment
.
Diseases
Validation
Diseases presenting
"facilitate the treatment of coats disease in children"
symptom
coats disease
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