Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Analysis of clinical misdiagnoses in children treated with enucleation.
[coats disease]
To
evaluate
discordant
clinical
and
pathological
diagnoses
leading
to
pediatric
enucleations
over
time
.
All
pathology
reports
of
pediatric
enucleation
specimens
(
subjects
aged
0
to
18
years
)
from
1960
to
2008
were
reviewed
.
Specimens
with
discordant
clinical
and
pathologic
diagnoses
were
further
analyzed
.
Formalin-fixed
,
paraffin-embedded
sections
of
enucleated
eyes
of
any
misdiagnosed
cases
were
reevaluated
.
Of
729
pediatric
patients
(
746
eyes
)
who
had
enucleation
from
1960
to
2008
,
29
patients
(
4
.
0
%
)
and
30
eyes
(
4
.
0
%
)
had
discordant
clinical
and
pathological
diagnoses
.
The
misdiagnosis
enucleation
rate
decreased
with
each
respective
decade
studied
,
with
the
highest
rate
of
6
.
5
%
(
18
of
276
eyes
)
in
the
1960
s
and
no
misdiagnoses
from
1990
to
2008
.
Of
the
369
eyes
enucleated
for
the
clinical
indication
of
malignancy
,
22
eyes
(
6
.
0
%
)
were
misdiagnosed
in
that
no
evidence
of
malignancy
was
found
on
histopathological
examination
.
Of
the
377
eyes
enucleated
for
benign
clinical
indications
,
7
cases
(
1
.
9
%
)
were
found
to
be
malignant
by
histopathology
.
Misdiagnoses
leading
to
pediatric
enucleation
have
decreased
during
the
past
5
decades
,
likely
owing
to
improved
diagnostic
techniques
.
Benign
and
malignant
intraocular
conditions
can
simulate
each
other
,
especially
retinoblastoma
,
Coats
disease
,
nematode
and
bacterial
endophthalmitis
,
panuveitis
,
and
persistent
hyperplastic
primary
vitreous
.
Diseases
Validation
Diseases presenting
"panuveitis"
symptom
coats disease
This symptom has already been validated
